Access

transcranial ultrasound parkinson s disease

Practice Point

Search Pubmed for

Transcranial ultrasound in the diagnosis of Parkinson's disease

WR Wayne Martin

Abstract

This Practice Point commentary discusses a prospective study by Gaenslen et al. regarding the diagnostic value of transcranial ultrasound in patients with early features of parkinsonism. Reference diagnoses were obtained on the basis of repeated clinical examination over the course of 1 year and by the performance of functional imaging in uncertain cases. Ultrasound at baseline had a sensitivity of 91% with a specificity of 82% for a diagnosis of idiopathic Parkinson's disease; the positive predictive value for idiopathic Parkinson's disease was 93% with a classification accuracy of 88%. While application of this technique in carefully selected patients may improve diagnostic accuracy, it is important to note that nigral changes similar to those observed in patients with Parkinson's disease occur in approximately 10% of healthy individuals and

have been reported in depression and essential tremor. The diagnosis of parkinsonian disorders continues to be based primarily on demonstration of characteristic neurological features.

To read this article in full you may need to log in, make a payment or gain access through a site license (see right).

Personal subscribers to Nature Reviews Neurology can view this article. To do this, associate your subscription with your registration via the My Account page. If you already have an active subscription, login here to your nature.com account. View our privacy policy and use of cookies .

If you do not have access to the article you require, you can purchase the article (see below) or access it through a site license. Institutions can add additional archived content to their license at any time. Recommend site license access to your institution.

I want to purchase this article

Category: Disease

Similar articles: